DESIGN OF EFFICIENT PACKET MARKING-BASED CONGESTION MANAGEMENT TECHNIQUES FOR CLUSTER INTERCONNECTS

El crecimiento de los computadores paralelos basados en redes de altas prestaciones ha aumentado el interés y esfuerzo de la comunidad investigadora en desarrollar nuevas técnicas que permitan obtener el mejor rendimiento de estas redes. En particular, el desarrollo de nuevas técnicas que permitan un encaminamiento eficiente y que reduzcan la latencia de los paquetes, aumentando así la productividad de la red. Sin embargo, una alta tasa de utilización de la red podría conllevar el que se conoce como "congestión de red", el cual puede causar una degradación del rendimiento. El control de la congestión en redes multietapa es un problema importante que no está completamente resuelto. Con el fin de evitar la degradación del rendimiento de la red cuando aparece congestión, se han propuesto diferentes mecanismos para el control de la congestión. Muchos de estos mecanismos están basados en notificación explícita de la congestión. Para este propósito, los switches detectan congestión y dependiendo de la estrategia aplicada, los paquetes son marcados con la finalidad de advertir a los nodos origenes. Como respuesta, los nodos origenes aplican acciones correctivas para ajustar su tasa de inyección de paquetes. El propósito de esta tesis es analizar las diferentes estratégias de detección y corrección de la congestión en redes multietapa, y proponer nuevos mecanismos de control de la congestión encaminados a este tipo de redes sin descarte de paquetes. Las nuevas propuestas están basadas en una estrategia más refinada de marcaje de paquetes en combinación con un conjunto de acciones correctivas justas que harán al mecanismo capaz de controlar la congestión de manera efectiva con independencia del grado de congestión y de las condiciones de tráfico.Ferrer Pérez, JL. (2012). DESIGN OF EFFICIENT PACKET MARKING-BASED CONGESTION MANAGEMENT TECHNIQUES FOR CLUSTER INTERCONNECTS [Tesis doctoral no publicada]. Universitat Politècnica de València. https://doi.org/10.4995/Thesis/10251/18197Palanci

Progressive congestion management based on packet marking and validation techniques

© 2012 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works.Congestion management in multistage interconnection networks is a serious problem, which is not solved completely. In order to avoid the degradation of network performance when congestion appears, several congestion management mechanisms have been proposed. Most of these mechanisms are based on explicit congestion notification. For this purpose, switches detect congestion and depending on the applied strategy, packets are marked to warn the source hosts. In response, source hosts apply some corrective actions to adjust their packet injection rate. Although these proposals seem quite effective, they either exhibit some drawbacks or are partial solutions. Some of them introduce some penalties over the flows not responsible for congestion, whereas others can cope only with congestion situations that last for a short time. In this paper, we present an overview of the different strategies to detect and correct congestion in multistage interconnection networks, and propose a new mechanism referred to as Marking and Validation Congestion Management (MVCM), targeted to this kind of lossless networks, and based on a more refined packet marking strategy combined with a fair set of corrective actions, that makes the mechanism able to effectively manage congestion regardless of the congestion degree. Evaluation results show the effectiveness and robustness of the proposed mechanism.This work was supported by the Spanish MEC and MICINN, as well as European Commission FEDER funds, under Grants CSD2006-00046 and TIN2009-14475-C04-01.Ferrer Pérez, JL.; Baydal Cardona, ME.; Robles Martínez, A.; López Rodríguez, PJ.; Duato Marín, JF. (2012). Progressive congestion management based on packet marking and validation techniques. IEEE Transactions on Computers. 61(9):1296-1309. doi:10.1109/TC.2011.146S1296130961

Cueva de La Cocina (Dos Aguas, Valencia) en el marco del Proyecto de Investigación Har2012-33111 “Meso Cocina: Los Últimos Caza-Recolectores y el Paradigma de la Neolitización en el Mediterráneo Peninsular”

Comunicación oral en el VI Congreso del Neolítico en la Península Ibérica: “Los cambios económicos y sus implicaciones sociales durante el Neolítico de la Península Ibérica”, 22-26 junio 2016 GranadaEl objetivo de esta comunicación es dar a conocer los resultados preliminares del proyecto HAR12-33111 “MesoCocina: los últimos caza-recolectores y el paradigma de la neolitización en el Mediterráneo peninsular” que ha tenido como eje de actuación el análisis pormenorizado del excepcional registro prehistórico recuperado en Cueva de la Cocina (Dos Aguas, Valencia). En el transcurso de los tres últimos años se ha procedido al análisis de las colecciones correspondientes a las excavaciones efectuadas por Ll. Pericot en los años 40 del pasado siglo así como aquellos resultados de las campañas dirigidas posteriormente por J. Fortea en los años 70. Al mismo tiempo se han llevado a cabo dos intervenciones de campo en la cavidad con el fin de obtener información precisa sobre las características de una secuencia clave a propósito de las ocupaciones del Mesolítico final en el Mediterráneo occidental, y que además contiene evidencias de frecuentaciones posteriores, desde el Neolítico Antiguo hasta la edad del Bronce. El establecimiento de un marco radiométrico preciso ha sido una de las prioridades junto a la reconstrucción tridimensional de todas las actuaciones realizadas hasta la fecha en el sitio. Bajo esta óptica procederemos a reevaluar la variabilidad de la cultura material, de las actividades de subsistencia, del mundo simbólico y las conexiones sociales en el entorno medioambiental donde se llevaron a cabo desde una amplia perspectiva diacrónica, entre el inicio del IX y el III milenio cal BP. Ciñéndonos al marco de este congreso nos centraremos especialmente en los nuevos datos relativos a la secuencia de los últimos caza-recolectores y el primer Neolítico en la cavidad.Peer Reviewe

Jardins per a la salut

Facultat de Farmàcia, Universitat de Barcelona. Ensenyament: Grau de Farmàcia. Assignatura: Botànica farmacèutica. Curs: 2014-2015. Coordinadors: Joan Simon, Cèsar Blanché i Maria Bosch.Els materials que aquí es presenten són el recull de les fitxes botàniques de 128 espècies presents en el Jardí Ferran Soldevila de l’Edifici Històric de la UB. Els treballs han estat realitzats manera individual per part dels estudiants dels grups M-3 i T-1 de l’assignatura Botànica Farmacèutica durant els mesos de febrer a maig del curs 2014-15 com a resultat final del Projecte d’Innovació Docent «Jardins per a la salut: aprenentatge servei a Botànica farmacèutica» (codi 2014PID-UB/054). Tots els treballs s’han dut a terme a través de la plataforma de GoogleDocs i han estat tutoritzats pels professors de l’assignatura. L’objectiu principal de l’activitat ha estat fomentar l’aprenentatge autònom i col·laboratiu en Botànica farmacèutica. També s’ha pretès motivar els estudiants a través del retorn de part del seu esforç a la societat a través d’una experiència d’Aprenentatge-Servei, deixant disponible finalment el treball dels estudiants per a poder ser consultable a través d’una Web pública amb la possibilitat de poder-ho fer in-situ en el propi jardí mitjançant codis QR amb un smartphone

The evolution of the ventilatory ratio is a prognostic factor in mechanically ventilated COVID-19 ARDS patients

Background: Mortality due to COVID-19 is high, especially in patients requiring mechanical ventilation. The purpose of the study is to investigate associations between mortality and variables measured during the first three days of mechanical ventilation in patients with COVID-19 intubated at ICU admission. Methods: Multicenter, observational, cohort study includes consecutive patients with COVID-19 admitted to 44 Spanish ICUs between February 25 and July 31, 2020, who required intubation at ICU admission and mechanical ventilation for more than three days. We collected demographic and clinical data prior to admission; information about clinical evolution at days 1 and 3 of mechanical ventilation; and outcomes. Results: Of the 2,095 patients with COVID-19 admitted to the ICU, 1,118 (53.3%) were intubated at day 1 and remained under mechanical ventilation at day three. From days 1 to 3, PaO2/FiO2 increased from 115.6 [80.0-171.2] to 180.0 [135.4-227.9] mmHg and the ventilatory ratio from 1.73 [1.33-2.25] to 1.96 [1.61-2.40]. In-hospital mortality was 38.7%. A higher increase between ICU admission and day 3 in the ventilatory ratio (OR 1.04 [CI 1.01-1.07], p = 0.030) and creatinine levels (OR 1.05 [CI 1.01-1.09], p = 0.005) and a lower increase in platelet counts (OR 0.96 [CI 0.93-1.00], p = 0.037) were independently associated with a higher risk of death. No association between mortality and the PaO2/FiO2 variation was observed (OR 0.99 [CI 0.95 to 1.02], p = 0.47). Conclusions: Higher ventilatory ratio and its increase at day 3 is associated with mortality in patients with COVID-19 receiving mechanical ventilation at ICU admission. No association was found in the PaO2/FiO2 variation

Traducción de documentos académicos. Aspectos singulares de la administración estadounidense

Curs 2020-2021La correcta traducción de la documentación administrativa, necesaria para la tramitación de una solicitud de equivalencia de estudios entre los sistemas educativos estadounidense y español de niveles no universitarios, requiere de un excelente conocimiento de la terminología específica en ambos idiomas. Este tipo de procesos administrativos están basados en normativa de dos países cuya reglamentación es muy estricta y exige una correcta traducción de la documentación original. Este trabajo se centra en la identificación y el análisis de algunos aspectos singulares de la documentación estadounidense, relacionada con trámites educativos, y de su traducción, ya que no están suficientemente definidas las equivalencias terminológicas en esta área. El estudio no solo pretende presentar de una manera clara y eficaz el proceso administrativo completo, sino aportar un repositorio de terminología básica relacionada con la administración educativa, así como de la documentación requerida para estos trámites, en función del nivel educativo.The correct translation of the administrative documentation necessary to process an application to obtain the equivalency of studies between the U.S. and Spanish educational systems, at non-university levels, requires an excellent knowledge of the specific terminology in both languages. This type of administrative processes is based on directives of two countries whose regulations are very strict and require a correct translation of the original documentation. This paper focuses on the identification and analysis of some unique aspects of the US documentation, related to educational procedures and their translation, since the terminological equivalences in this field are not sufficiently defined. The study aims, not only to present in a clear and efficient way the complete administrative process, but also to provide a repository of the basic terminology related to educational administration, as well as the necessary documentation for these procedures, depending on the educational level.Director/a: Eva Espasa Borrà

Therapeutic drug monitoring of vancomycin concentrations for the management of bone and joint infections: an urgent need

Vancomycin is used for the treatment of bone and joint infections (BJI), but scarce information is available about its pharmacokinetic/pharmacodynamic (PK/PD) characteristics. We aimed to identify the risk factors associated with the non-achievement of an optimal PK/PD target in the first therapeutic drug monitoring (TDM). Methods: A retrospective study was conducted in a tertiary hospital from January 2020 to January 2022. Patients with BJI and TDM of vancomycin on day 2 of treatment were included. Initial vancomycin fixed doses (1 g every 8 h or 12 h) was decided by the responsible doctors. According to TDM results, dosage adjustments were performed. An AUC24h/MIC 600 mg × h/L, were defined as suboptimal, optimal and supratherapeutic, respectively. Patients were grouped into these three categories. Demographic, clinical and PK characteristics were compared between groups. Nephrotoxicity at the end of treatment was assessed. Results: A total of 94 patients were included: 22 (23.4%), 42 (44.7%) and 30 (31.9%) presented an infratherapeutic, optimal and supratherapeutic PK/PD targets, respectively. A younger age and initial vancomycin dose 40 mg/kg/day were associated with overexposure. The nephrotoxicity rate was 22.7%. More than 50% of patients did not achieve an optimal PK/PD. Considering age, baseline serum-creatinine and body weight, TDM is required to readily achieve an optimal and safe exposure

Relationship between the ABO blood group and COVID-19 susceptibility, severity and mortality in two cohorts of patients

Background - Several articles reported the existence of an association between ABO blood groups and COVID-19 susceptibility. Group A and group O individuals showed a higher and lower risk, respectively, of becoming infected. No association was observed between ABO groups and mortality. To verify this association, we performed a retrospective study of two cohorts of patients with different demographic and clinical characteristics. Material and methods - A total of 854 regular blood donors were recruited for convalescent plasma donation after recovering from a mild COVID-19 infection, and a group of 965 patients more severely affected who were transfused during hospitalisation were also included. We also investigated the potential role of the different risk factors on patient outcome and death. To eliminate the confounding effect of risk factors on mortality, a propensity score analysis was performed. Results - Blood group A and blood group O COVID-19 blood donors showed a higher and lower risk, respectively, for acquiring COVID-19. In contrast, this association was not found in the group of patients transfused during hospitalisation, probably due to the great differences in demographic and clinical characteristics between the two groups. Regarding severity, age was one of the most significant risk factors. ABO blood groups were also seen to represent important risk factors for COVID-19 severity and mortality. Mortality risk in group A individuals was significantly higher than in group O individuals (OR: 1.75, 95% CI: 1.22-2.51). Discussion - The association between the ABO blood groups and the susceptibility to acquire COVID-19 infection was confirmed in the group of blood donors. ABO blood groups were also associated to COVID-19 severity and mortality in the group of patients transfused during hospitalisation. Therefore, blood groups A and O are two important factors to be considered when evaluating the prognosis of patients with COVID-19

Influence of the length of hospitalisation in post-discharge outcomes in patients with acute heart failure: Results of the LOHRCA study.

To investigate the relationship between length of hospitalisation (LOH) and post-discharge outcomes in acute heart failure (AHF) patients and to ascertain whether there are different patterns according to department of initial hospitalisation. Consecutive AHF patients hospitalised in 41 Spanish centres were grouped based on the LOH (15 days). Outcomes were defined as 90-day post-discharge all-cause mortality, AHF readmissions, and the combination of both. Hazard ratios (HRs), adjusted by chronic conditions and severity of decompensation, were calculated for groups with LOH >6 days vs. LOH 6 days vs. LOH We included 8563 patients (mean age: 80 (SD = 10) years, 55.5% women), with a median LOH of 7 days (IQR 4-11): 2934 (34.3%) had a LOH 15 days. The 90-day post-discharge mortality was 11.4%, readmission 32.2%, and combined endpoint 37.4%. Mortality was increased by 36.5% (95%CI = 13.0-64.9) when LOH was 11-15 days, and by 72.0% (95%CI = 42.6-107.5) when >15 days. Conversely, no differences were found in readmission risk, and the combined endpoint only increased 21.6% (95%CI = 8.4-36.4) for LOH >15 days. Stratified analysis by hospitalisation departments rendered similar post-discharge outcomes, with all exhibiting increased mortality for LOH >15 days and no significant increments in readmission risk. Short hospitalisations are not associated with worse outcomes. While post-discharge readmissions are not affected by LOH, mortality risk increases as the LOH lengthens. These findings were similar across hospitalisation departments